Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

ZKSCAN7

zinc finger with KRAB and SCAN domains 7

translation score 0.45, read 2026-10-28; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocyte progenitor cells; strongest in late spermatids0.75
chemistry
Open Targets		hard to drug0.00
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		no papers tie it to Parkinson's yet1.00
pathways
Reactome		1 pathway; mostly other0.30

No case: the score is under the bar. Receipt 12729

Sealed predictions

  1. ZKSCAN7 in dopamine neurons, braak-0.18 (p 0.639) → +0.54 (p 0.130)receipt 12738
  2. ZKSCAN7 in oligodendrocytes, braak+0.29 (p 0.443) → -0.25 (p 0.514)receipt 12737

Swarm cases

receipt 12738: ZKSCAN7 in dopamine neurons, braak

power
full sample +0.18 (p 0.487, n 18), 95% CI -0.32 to +0.59. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.15 (p 0.555, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.23 (p 0.369, n 18). could be the mix.
skeptic
leave-one-out range +0.07 to +0.27, sign flips 0; without severely affected donors +0.18 (p 0.487, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ZKSCAN7 in dopamine neurons.

case closed: nothing better to follow up.

receipt 12737: ZKSCAN7 in oligodendrocytes, braak

power
full sample +0.19 (p 0.444, n 18), 95% CI -0.30 to +0.60. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.22 (p 0.379, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.17 (p 0.504, n 18). could be the mix.
skeptic
leave-one-out range +0.07 to +0.33, sign flips 0; without severely affected donors +0.19 (p 0.444, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ZKSCAN7 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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