Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

ZIC2

Zic family zinc finger 2

translation score 0.42, read 2026-10-22; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.03 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced, including brain excitatory neurons; strongest in bergmann glia0.75
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
2 Parkinson's papers of 3740.85
pathways
Reactome
1 pathway; mostly other0.30

No case: the score is under the bar. Receipt 6378

Sealed predictions

  1. ZIC2 in dopamine neurons, braakn/a → n/areceipt 6386

Swarm cases

receipt 6386: ZIC2 in dopamine neurons, braak

cell type
ZIC2 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ZIC2 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

loading the receipts