Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.10 (overall 0.06) | 0.10 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 47 | 0.82 |
| pathways Reactome | 2 pathways; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 4383
Sealed predictions
- ZDHHC2 in dopamine neurons, braak-0.06 (p 0.873) → +0.04 (p 0.912)receipt 4390
Swarm cases
receipt 4390: ZDHHC2 in dopamine neurons, braak
- power
- full sample -0.05 (p 0.847, n 18), 95% CI -0.50 to +0.43. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.05 (p 0.834, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.02 (p 0.942, n 18). could be the mix.
- skeptic
- leave-one-out range -0.19 to +0.07, sign flips 3; without severely affected donors -0.05 (p 0.847, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ZDHHC2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts