Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in bergmann glia | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 38 | 0.91 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 15345
Sealed predictions
- ZDHHC14 in dopamine neurons, braak-0.30 (p 0.436) → -0.18 (p 0.635)receipt 15353
- ZDHHC14 in oligodendrocytes, braak-0.36 (p 0.348) → +0.04 (p 0.909)receipt 15352
Swarm cases
receipt 15353: ZDHHC14 in dopamine neurons, braak
- power
- full sample -0.32 (p 0.201, n 18), 95% CI -0.68 to +0.18. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.34 (p 0.164, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.35 (p 0.156, n 18). could be the mix.
- skeptic
- leave-one-out range -0.40 to -0.23, sign flips 0; without severely affected donors -0.32 (p 0.201, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ZDHHC14 in dopamine neurons.
case closed: nothing better to follow up.
receipt 15352: ZDHHC14 in oligodendrocytes, braak
- power
- full sample -0.28 (p 0.254, n 18), 95% CI -0.66 to +0.21. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.38 (p 0.123, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.40 (p 0.097, n 18). could be the mix.
- skeptic
- leave-one-out range -0.43 to -0.19, sign flips 0; without severely affected donors -0.28 (p 0.254, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ZDHHC14 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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