parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.14 (overall 0.09)	0.14
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in late primary spermatocytes	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 3066

ZCWPW2 in dopamine neurons, braak+0.84 (p 0.005) → +0.21 (p 0.581)receipt 3074
ZCWPW2 in astrocytes, braak-0.53 (p 0.146) → +0.16 (p 0.689)receipt 3073

receipt 3074: ZCWPW2 in dopamine neurons, braak

power: full sample +0.48 (p 0.043, n 18), 95% CI +0.02 to +0.77. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: +0.49 (p 0.041, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.51 (p 0.031, n 18). not the mix.
skeptic: leave-one-out range +0.41 to +0.64, sign flips 0; without severely affected donors +0.48 (p 0.043, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ZCWPW2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 3073: ZCWPW2 in astrocytes, braak

power: full sample -0.21 (p 0.398, n 18), 95% CI -0.62 to +0.28. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.11 (p 0.671, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.13 (p 0.609, n 18). could be the mix.
skeptic: leave-one-out range -0.37 to -0.12, sign flips 0; without severely affected donors -0.21 (p 0.398, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ZCWPW2 in astrocytes.

case closed: nothing better to follow up.

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