Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.04 (overall 0.47) | 0.04 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: selinexor | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 5 Parkinson's papers of 933 | 0.76 |
| pathways Reactome | 19 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 0294
Sealed predictions
- XPO1 in dopamine neurons, braak+0.24 (p 0.539) → +0.15 (p 0.699)receipt 0300
Swarm cases
receipt 0300: XPO1 in dopamine neurons, braak
- power
- full sample +0.23 (p 0.360, n 18), 95% CI -0.27 to +0.63. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.24 (p 0.328, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.45 (p 0.063, n 18). could be the mix.
- skeptic
- leave-one-out range +0.14 to +0.38, sign flips 0; without severely affected donors +0.23 (p 0.360, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for XPO1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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