Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (breast lactating cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: topiroxostat, bendazac, allopurinol sodium +3 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 995 | 0.82 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3448
Sealed predictions
- XDH in dopamine neurons, braak-0.90 (p 0.001) → +0.72 (p 0.028)receipt 3455
Swarm cases
receipt 3455: XDH in dopamine neurons, braak
- power
- full sample +0.19 (p 0.460, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.18 (p 0.471, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.03 (p 0.908, n 18). could be the mix.
- skeptic
- leave-one-out range +0.09 to +0.33, sign flips 0; without severely affected donors +0.19 (p 0.460, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for XDH in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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