Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.10 (overall 0.06) | 0.10 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (podocytes) | 0.10 |
| chemistry Open Targets | hard to drug: ombipepimut-s, galinpepimut-s | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 7,903 | 0.82 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 4187
Sealed predictions
- WT1 in dopamine neurons, braak+0.49 (p 0.181) → -0.03 (p 0.947)receipt 4193
Swarm cases
receipt 4193: WT1 in dopamine neurons, braak
- power
- full sample +0.06 (p 0.827, n 18), 95% CI -0.42 to +0.51. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.09 (p 0.722, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.03 (p 0.915, n 18). could be the mix.
- skeptic
- leave-one-out range -0.08 to +0.17, sign flips 5; without severely affected donors +0.06 (p 0.827, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for WT1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts