Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 14 Parkinson's papers of 6,834 | 0.64 |
| pathways Reactome | 7 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 6523
Sealed predictions
- VHL in dopamine neurons, braak+0.11 (p 0.775) → +0.06 (p 0.869)receipt 6529
Swarm cases
receipt 6529: VHL in dopamine neurons, braak
- power
- full sample -0.00 (p 0.990, n 18), 95% CI -0.47 to +0.46. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.04 (p 0.881, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.05 (p 0.847, n 18). could be the mix.
- skeptic
- leave-one-out range -0.16 to +0.07, sign flips 13; without severely affected donors -0.00 (p 0.990, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for VHL in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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