Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 63 Parkinson's papers of 1,590 | 0.45 |
| pathways Reactome | 5 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 3930
Sealed predictions
- VDAC1 in dopamine neurons, braak+0.34 (p 0.378) → -0.61 (p 0.084)receipt 3939
In the sealed studies
- Mitochondrial quality control and Lewy stage: did not hold
Swarm cases
receipt 3939: VDAC1 in dopamine neurons, braak
- power
- full sample -0.26 (p 0.294, n 18), 95% CI -0.65 to +0.23. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.26 (p 0.298, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.26 (p 0.298, n 18). could be the mix.
- skeptic
- leave-one-out range -0.36 to -0.15, sign flips 0; without severely affected donors -0.26 (p 0.294, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for VDAC1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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