Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.13 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 19 Parkinson's papers of 456 | 0.61 |
| pathways Reactome | 6 pathways; mostly lysosome and autophagy | 1.00 |
No case: the score is under the bar. Receipt 2255
Sealed predictions
- VAPB in dopamine neurons, braak+0.32 (p 0.406) → +0.04 (p 0.911)receipt 2261
Swarm cases
receipt 2261: VAPB in dopamine neurons, braak
- power
- full sample +0.26 (p 0.302, n 18), 95% CI -0.24 to +0.65. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.30 (p 0.221, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.32 (p 0.194, n 18). could be the mix.
- skeptic
- leave-one-out range +0.15 to +0.37, sign flips 0; without severely affected donors +0.26 (p 0.302, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for VAPB in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts