Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 5 Parkinson's papers of 485 | 0.76 |
| pathways Reactome | 3 pathways; mostly lysosome and autophagy | 1.00 |
No case: the score is under the bar. Receipt 10303
Sealed predictions
- VAPA in dopamine neurons, braak+0.74 (p 0.024) → +0.49 (p 0.181)receipt 10310
Swarm cases
receipt 10310: VAPA in dopamine neurons, braak
- power
- full sample +0.50 (p 0.034, n 18), 95% CI +0.04 to +0.78. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.50 (p 0.034, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.45 (p 0.063, n 18). could be the mix.
- skeptic
- leave-one-out range +0.43 to +0.63, sign flips 0; without severely affected donors +0.50 (p 0.034, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for VAPA in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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