Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.40 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in other brain neurons (333 nCPM) | 1.00 |
| chemistry Open Targets | reachable by antibody: rimabotulinumtoxinb | 0.45 |
| trials ClinicalTrials.gov | 3 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 52 Parkinson's papers of 981 | 0.48 |
| pathways Reactome | 22 pathways; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 0631
Sealed predictions
- VAMP2 in dopamine neurons, braak+0.40 (p 0.291) → -0.46 (p 0.214)receipt 0637
Swarm cases
receipt 0637: VAMP2 in dopamine neurons, braak
- power
- full sample -0.08 (p 0.767, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.16 (p 0.515, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.03 (p 0.908, n 18). could be the mix.
- skeptic
- leave-one-out range -0.21 to +0.04, sign flips 1; without severely affected donors -0.08 (p 0.767, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for VAMP2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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