Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in thyrotrophs | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 66 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 15106
Sealed predictions
- UNC80 in dopamine neurons, braak+0.87 (p 0.002) → +0.00 (p 1.000)receipt 15114
- UNC80 in oligodendrocytes, braak+0.14 (p 0.718) → +0.07 (p 0.849)receipt 15113
Swarm cases
receipt 15114: UNC80 in dopamine neurons, braak
- power
- full sample +0.40 (p 0.103, n 18), 95% CI -0.09 to +0.73. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.41 (p 0.089, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.44 (p 0.066, n 18). could be the mix.
- skeptic
- leave-one-out range +0.34 to +0.60, sign flips 0; without severely affected donors +0.40 (p 0.103, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for UNC80 in dopamine neurons.
case closed: nothing better to follow up.
receipt 15113: UNC80 in oligodendrocytes, braak
- power
- full sample +0.06 (p 0.820, n 18), 95% CI -0.42 to +0.51. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.04 (p 0.888, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.03 (p 0.915, n 18). could be the mix.
- skeptic
- leave-one-out range -0.05 to +0.20, sign flips 4; without severely affected donors +0.06 (p 0.820, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for UNC80 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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