parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in microglia (135 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	6 Parkinson's papers of 211	0.74
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 9626

receipt 9634: ULK2 in dopamine neurons, braak

power: full sample +0.20 (p 0.424, n 18), 95% CI -0.29 to +0.61. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.17 (p 0.509, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.13 (p 0.621, n 18). could be the mix.
skeptic: leave-one-out range +0.11 to +0.35, sign flips 0; without severely affected donors +0.20 (p 0.424, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ULK2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 9633: ULK2 in microglia, braak

power: full sample -0.37 (p 0.127, n 18), 95% CI -0.72 to +0.11. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.33 (p 0.182, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.31 (p 0.204, n 18). could be the mix.
skeptic: leave-one-out range -0.52 to -0.29, sign flips 0; without severely affected donors -0.37 (p 0.127, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ULK2 in microglia.

case closed: nothing better to follow up.

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