Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in pancreatic acinar cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 4 Parkinson's papers of 1,397 | 0.79 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 8495
Sealed predictions
- UCN in dopamine neurons, braakn/a → n/areceipt 8504
- UCN in oligodendrocytes, braak+0.11 (p 0.785) → -0.78 (p 0.014)receipt 8503
Swarm cases
receipt 8504: UCN in dopamine neurons, braak
- cell type
- UCN is not measured in dopamine neurons; looking elsewhere.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for UCN in dopamine neurons.
case closed: nothing better to follow up.
receipt 8503: UCN in oligodendrocytes, braak
- power
- full sample -0.31 (p 0.218, n 18), 95% CI -0.68 to +0.19. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.34 (p 0.173, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.36 (p 0.145, n 18). could be the mix.
- skeptic
- leave-one-out range -0.51 to -0.23, sign flips 0; without severely affected donors -0.31 (p 0.218, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for UCN in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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