Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.20 (overall 0.13) | 0.20 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 12 Parkinson's papers of 441 | 0.66 |
| pathways Reactome | 6 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 2260
Sealed predictions
- TYROBP in dopamine neurons, braak+0.66 (p 0.053) → -0.53 (p 0.138)receipt 2266
Swarm cases
receipt 2266: TYROBP in dopamine neurons, braak
- power
- full sample +0.08 (p 0.761, n 18), 95% CI -0.40 to +0.53. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.12 (p 0.640, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.13 (p 0.609, n 18). could be the mix.
- skeptic
- leave-one-out range +0.00 to +0.24, sign flips 0; without severely affected donors +0.08 (p 0.761, n 18). fragile.
- cell type
- strongest in astrocytes: +0.69 (p 0.0017, n 18) vs +0.08 in dopamine neurons. proposing astrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TYROBP in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up TYROBP · astrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.10 p 0.722 (needs p < 7.0e-4)
Receipts
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