Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (melanocytes) | 0.10 |
| chemistry Open Targets | compounds already reach it: monobenzone, arbutin | 1.00 |
| trials ClinicalTrials.gov | 135 Parkinson's trials, 4 stopped | 0.94 |
| literature PubMed | 154 Parkinson's papers of 32,377 | 0.34 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 7287
Sealed predictions
- TYR in dopamine neurons, braak-0.62 (p 0.073) → +0.42 (p 0.255)receipt 7294
Swarm cases
receipt 7294: TYR in dopamine neurons, braak
- power
- full sample +0.01 (p 0.983, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.07 (p 0.787, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.07 (p 0.787, n 18). could be the mix.
- skeptic
- leave-one-out range -0.14 to +0.15, sign flips 7; without severely affected donors +0.01 (p 0.983, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TYR in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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