Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 7 Parkinson's papers of 2,614 | 0.73 |
| pathways Reactome | 5 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 11936
Sealed predictions
- TWIST1 in dopamine neurons, braak+0.35 (p 0.354) → +0.90 (p 0.001)receipt 11943
Swarm cases
receipt 11943: TWIST1 in dopamine neurons, braak
- power
- full sample +0.55 (p 0.017, n 18), 95% CI +0.12 to +0.81. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.56 (p 0.017, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.66 (p 0.0030, n 18). not the mix.
- skeptic
- leave-one-out range +0.50 to +0.75, sign flips 0; without severely affected donors +0.55 (p 0.017, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TWIST1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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