parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.06 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including oligodendrocytes; strongest in retinal horizontal cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	4 Parkinson's papers of 66	0.79
pathways Reactome	Reactome did not answer (Reactome: The operation was aborted due to timeout)	0.00

No case: the score is under the bar. Receipt 4307

receipt 4315: TTBK1 in dopamine neurons, braak

power: full sample -0.36 (p 0.145, n 18), 95% CI -0.71 to +0.13. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.38 (p 0.120, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.49 (p 0.040, n 18). not the mix.
skeptic: leave-one-out range -0.47 to -0.27, sign flips 0; without severely affected donors -0.36 (p 0.145, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TTBK1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 4314: TTBK1 in oligodendrocytes, braak

power: full sample -0.31 (p 0.207, n 18), 95% CI -0.68 to +0.18. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.38 (p 0.125, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.21 (p 0.408, n 18). could be the mix.
skeptic: leave-one-out range -0.51 to -0.24, sign flips 0; without severely affected donors -0.31 (p 0.207, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TTBK1 in oligodendrocytes.

case closed: nothing better to follow up.

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