Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.24 |
| trials ClinicalTrials.gov | 28 Parkinson's trials, 3 stopped | 0.91 |
| literature PubMed | 58 Parkinson's papers of 8,695 | 0.46 |
| pathways Reactome | 2 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 10713
Sealed predictions
- TST in dopamine neurons, braak+0.30 (p 0.428) → -0.39 (p 0.300)receipt 10720
Swarm cases
receipt 10720: TST in dopamine neurons, braak
- power
- full sample -0.08 (p 0.741, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.11 (p 0.677, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.11 (p 0.677, n 18). could be the mix.
- skeptic
- leave-one-out range -0.24 to +0.05, sign flips 1; without severely affected donors -0.08 (p 0.741, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TST in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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