Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 21 Parkinson's papers of 3,805 | 0.59 |
| pathways Reactome | 7 pathways; mostly lysosome and autophagy | 1.00 |
No case: the score is under the bar. Receipt 6953
Sealed predictions
- TSC2 in dopamine neurons, braak-0.59 (p 0.096) → -0.04 (p 0.928)receipt 6960
Swarm cases
receipt 6960: TSC2 in dopamine neurons, braak
- power
- full sample -0.45 (p 0.060, n 18), 95% CI -0.76 to +0.02. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.52 (p 0.026, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.55 (p 0.018, n 18). not the mix.
- skeptic
- leave-one-out range -0.56 to -0.37, sign flips 0; without severely affected donors -0.45 (p 0.060, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TSC2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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