Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 14 Parkinson's papers of 2,984 | 0.64 |
| pathways Reactome | 5 pathways; mostly lysosome and autophagy | 1.00 |
No case: the score is under the bar. Receipt 10793
Sealed predictions
- TSC1 in dopamine neurons, braak-0.68 (p 0.045) → -0.60 (p 0.089)receipt 10801
Swarm cases
receipt 10801: TSC1 in dopamine neurons, braak
- power
- full sample -0.57 (p 0.013, n 18), 95% CI -0.82 to -0.14. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.62 (p 0.0060, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.59 (p 0.0092, n 18). not the mix.
- skeptic
- leave-one-out range -0.64 to -0.51, sign flips 0; without severely affected donors -0.57 (p 0.013, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TSC1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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