Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (prostatic glandular cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: elismetrep, d-3263, menthol | 1.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 8 Parkinson's papers of 1,837 | 0.71 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3452
Sealed predictions
- TRPM8 in dopamine neurons, braak-0.51 (p 0.160) → +0.17 (p 0.665)receipt 3459
Swarm cases
receipt 3459: TRPM8 in dopamine neurons, braak
- power
- full sample -0.20 (p 0.418, n 18), 95% CI -0.61 to +0.29. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.18 (p 0.487, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.30 (p 0.228, n 18). could be the mix.
- skeptic
- leave-one-out range -0.33 to -0.10, sign flips 0; without severely affected donors -0.20 (p 0.418, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TRPM8 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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