parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.10 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in microglia (178 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	2 Parkinson's trials, 0 stopped	1.00
literature PubMed	40 Parkinson's papers of 1,267	0.51
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 2715

receipt 2723: TRPM2 in dopamine neurons, braak

power: full sample -0.15 (p 0.555, n 18), 95% CI -0.58 to +0.34. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.16 (p 0.515, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.38 (p 0.123, n 18). could be the mix.
skeptic: leave-one-out range -0.28 to -0.04, sign flips 0; without severely affected donors -0.15 (p 0.555, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TRPM2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2722: TRPM2 in microglia, braak

power: full sample -0.16 (p 0.515, n 18), 95% CI -0.59 to +0.33. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.10 (p 0.683, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.09 (p 0.715, n 18). could be the mix.
skeptic: leave-one-out range -0.34 to -0.05, sign flips 0; without severely affected donors -0.16 (p 0.515, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TRPM2 in microglia.

case closed: nothing better to follow up.

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