Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in retinal horizontal cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 59 | 0.91 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 4071
Sealed predictions
- TRIM67 in oligodendrocytes, braak-0.41 (p 0.269) → +0.04 (p 0.927)receipt 4078
- TRIM67 in dopamine neurons, braak+0.14 (p 0.718) → -0.39 (p 0.298)receipt 4079
Swarm cases
receipt 4079: TRIM67 in dopamine neurons, braak
- power
- full sample -0.15 (p 0.555, n 18), 95% CI -0.58 to +0.34. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.12 (p 0.627, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.42 (p 0.080, n 18). could be the mix.
- skeptic
- leave-one-out range -0.29 to -0.05, sign flips 0; without severely affected donors -0.15 (p 0.555, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TRIM67 in dopamine neurons.
case closed: nothing better to follow up.
receipt 4078: TRIM67 in oligodendrocytes, braak
- power
- full sample +0.00 (p 0.990, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.00 (p 0.997, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.26 (p 0.294, n 18). could be the mix.
- skeptic
- leave-one-out range -0.08 to +0.14, sign flips 8; without severely affected donors +0.00 (p 0.990, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TRIM67 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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