Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 75 | 0.82 |
| pathways Reactome | 1 pathway; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 3360
Sealed predictions
- TRIM3 in dopamine neurons, braak-0.61 (p 0.078) → -0.23 (p 0.551)receipt 3367
Swarm cases
receipt 3367: TRIM3 in dopamine neurons, braak
- power
- full sample -0.40 (p 0.103, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.40 (p 0.103, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.58 (p 0.011, n 18). not the mix.
- skeptic
- leave-one-out range -0.49 to -0.32, sign flips 0; without severely affected donors -0.40 (p 0.103, n 18). fragile.
- cell type
- strongest in microglia: -0.59 (p 0.0096, n 18) vs -0.40 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TRIM3 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up TRIM3 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.28 p 0.328 (needs p < 5.6e-4)
Receipts
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