Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (müller glia) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 42 Parkinson's papers of 12,094 | 0.51 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6641
Sealed predictions
- TRH in dopamine neurons, braak-0.47 (p 0.207) → -0.04 (p 0.928)receipt 6648
Swarm cases
receipt 6648: TRH in dopamine neurons, braak
- power
- full sample -0.16 (p 0.521, n 18), 95% CI -0.58 to +0.33. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.15 (p 0.544, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.19 (p 0.450, n 18). could be the mix.
- skeptic
- leave-one-out range -0.34 to -0.08, sign flips 0; without severely affected donors -0.16 (p 0.521, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TRH in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts