Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.15 (overall 0.10) | 0.15 |
| cell type Human Protein Atlas | cell type enriched outside the brain (platelets) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 32 | 0.82 |
| pathways Reactome | 1 pathway; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 2724
Sealed predictions
- TREML1 in dopamine neurons, braak-0.22 (p 0.563) → -0.69 (p 0.042)receipt 2730
Swarm cases
receipt 2730: TREML1 in dopamine neurons, braak
- power
- full sample -0.46 (p 0.057, n 18), 95% CI -0.76 to +0.01. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.36 (p 0.137, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.35 (p 0.156, n 18). could be the mix.
- skeptic
- leave-one-out range -0.61 to -0.38, sign flips 0; without severely affected donors -0.46 (p 0.057, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TREML1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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