Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.11 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (hofbauer cells) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 4 Parkinson's trials, 1 stopped | 0.80 |
| literature PubMed | 170 Parkinson's papers of 3,075 | 0.32 |
| pathways Reactome | 4 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 2418
Sealed predictions
- TREM2 in dopamine neurons, braak-0.29 (p 0.449) → +0.45 (p 0.227)receipt 2425
In the sealed studies
- An antigen-presenting microglial response: did not hold
Swarm cases
receipt 2425: TREM2 in dopamine neurons, braak
- power
- full sample +0.07 (p 0.787, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.08 (p 0.741, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.08 (p 0.748, n 18). could be the mix.
- skeptic
- leave-one-out range -0.02 to +0.23, sign flips 2; without severely affected donors +0.07 (p 0.787, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TREM2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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