Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 2 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 6525
Sealed predictions
- TRAPPC9 in dopamine neurons, braak-0.67 (p 0.050) → -0.30 (p 0.428)receipt 6531
Swarm cases
receipt 6531: TRAPPC9 in dopamine neurons, braak
- power
- full sample -0.35 (p 0.153, n 18), 95% CI -0.70 to +0.14. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.36 (p 0.140, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.53 (p 0.023, n 18). not the mix.
- skeptic
- leave-one-out range -0.47 to -0.27, sign flips 0; without severely affected donors -0.35 (p 0.153, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TRAPPC9 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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