Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (late spermatids) | 0.10 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 19 | 0.85 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 8788
Sealed predictions
- TPPP2 in dopamine neurons, braak-0.76 (p 0.019) → +0.21 (p 0.586)receipt 8796
Swarm cases
receipt 8796: TPPP2 in dopamine neurons, braak
- power
- full sample -0.36 (p 0.142, n 18), 95% CI -0.71 to +0.13. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.46 (p 0.056, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.67 (p 0.0024, n 18). not the mix.
- skeptic
- leave-one-out range -0.52 to -0.28, sign flips 0; without severely affected donors -0.36 (p 0.142, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TPPP2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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