parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.10 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in adrenal cortex cells	0.75
chemistry Open Targets	a small-molecule pocket	0.50
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	6 Parkinson's papers of 611	0.74
pathways Reactome	1 pathway; mostly protein handling	0.90

No case: the score is under the bar. Receipt 2688

receipt 2696: TPP1 in dopamine neurons, braak

power: full sample +0.14 (p 0.579, n 18), 95% CI -0.35 to +0.57. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.22 (p 0.384, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.22 (p 0.384, n 18). could be the mix.
skeptic: leave-one-out range +0.06 to +0.32, sign flips 0; without severely affected donors +0.14 (p 0.579, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TPP1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2695: TPP1 in astrocytes, braak

power: full sample -0.19 (p 0.455, n 18), 95% CI -0.60 to +0.31. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.18 (p 0.476, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.02 (p 0.928, n 18). could be the mix.
skeptic: leave-one-out range -0.31 to -0.09, sign flips 0; without severely affected donors -0.19 (p 0.455, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TPP1 in astrocytes.

case closed: nothing better to follow up.

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