Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (oocytes) | 0.10 |
| chemistry Open Targets | compounds already reach it: methimazole, propylthiouracil, carbimazole | 1.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 4 Parkinson's papers of 7,655 | 0.79 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 7991
Sealed predictions
- TPO in dopamine neurons, braak-0.16 (p 0.672) → -0.63 (p 0.068)receipt 7997
Swarm cases
receipt 7997: TPO in dopamine neurons, braak
- power
- full sample -0.38 (p 0.125, n 18), 95% CI -0.72 to +0.11. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.40 (p 0.103, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.54 (p 0.021, n 18). not the mix.
- skeptic
- leave-one-out range -0.52 to -0.30, sign flips 0; without severely affected donors -0.38 (p 0.125, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TPO in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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