Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | enriched in the midbrain (632 nTPM), where the nigral dopamine neurons sit | 0.90 |
| chemistry Open Targets | compounds already reach it: telotristat, telotristat ethyl, telotristat etiprate | 1.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 20 Parkinson's papers of 1,231 | 0.60 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 5509
Sealed predictions
- TPH2 in dopamine neurons, braak+0.38 (p 0.309) → +0.41 (p 0.277)receipt 5518
Swarm cases
receipt 5518: TPH2 in dopamine neurons, braak
- power
- full sample +0.38 (p 0.116, n 18), 95% CI -0.10 to +0.72. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.37 (p 0.132, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.28 (p 0.269, n 18). could be the mix.
- skeptic
- leave-one-out range +0.29 to +0.53, sign flips 0; without severely affected donors +0.38 (p 0.116, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TPH2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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