Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (respiratory deuterosomal cells) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 511 | 0.85 |
| pathways Reactome | 8 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 4281
Sealed predictions
- TP73 in dopamine neurons, braak-0.76 (p 0.017) → -0.08 (p 0.838)receipt 4288
Swarm cases
receipt 4288: TP73 in dopamine neurons, braak
- power
- full sample -0.43 (p 0.075, n 18), 95% CI -0.75 to +0.05. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.43 (p 0.079, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.53 (p 0.023, n 18). not the mix.
- skeptic
- leave-one-out range -0.57 to -0.36, sign flips 0; without severely affected donors -0.43 (p 0.075, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TP73 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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