Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in ependymal cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 8661
Sealed predictions
- TNNI3K in dopamine neurons, braak+0.64 (p 0.063) → +0.53 (p 0.143)receipt 8669
- TNNI3K in oligodendrocytes, braak-0.35 (p 0.360) → -0.32 (p 0.400)receipt 8668
Swarm cases
receipt 8669: TNNI3K in dopamine neurons, braak
- power
- full sample +0.46 (p 0.054, n 18), 95% CI -0.01 to +0.76. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.40 (p 0.101, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.39 (p 0.111, n 18). could be the mix.
- skeptic
- leave-one-out range +0.39 to +0.60, sign flips 0; without severely affected donors +0.46 (p 0.054, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TNNI3K in dopamine neurons.
case closed: nothing better to follow up.
receipt 8668: TNNI3K in oligodendrocytes, braak
- power
- full sample -0.27 (p 0.281, n 18), 95% CI -0.65 to +0.23. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.31 (p 0.211, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.28 (p 0.265, n 18). could be the mix.
- skeptic
- leave-one-out range -0.41 to -0.16, sign flips 0; without severely affected donors -0.27 (p 0.281, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TNNI3K in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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