Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

TNFRSF4

TNF receptor superfamily member 4

translation score 0.45, read 2026-10-23; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.02 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced outside the brain (innate lymphoid cells)0.10
chemistry
Open Targets
compounds already reach it: gsk-3174998, ivuxolimab, medi-6469 +20.81
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
1 pathway; mostly other0.30

No case: the score is under the bar. Receipt 7975

Sealed predictions

  1. TNFRSF4 in dopamine neurons, braakn/a → n/areceipt 7983

Swarm cases

receipt 7983: TNFRSF4 in dopamine neurons, braak

cell type
TNFRSF4 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TNFRSF4 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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