Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 11032
Sealed predictions
- TNFRSF14 in dopamine neurons, braak-0.65 (p 0.059) → -0.55 (p 0.127)receipt 11040
Swarm cases
receipt 11040: TNFRSF14 in dopamine neurons, braak
- power
- full sample -0.53 (p 0.024, n 18), 95% CI -0.80 to -0.08. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.52 (p 0.026, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.58 (p 0.011, n 18). not the mix.
- skeptic
- leave-one-out range -0.64 to -0.46, sign flips 0; without severely affected donors -0.53 (p 0.024, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TNFRSF14 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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