Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 41 | 0.91 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 5831
Sealed predictions
- TMPRSS11D in dopamine neurons, braak-0.04 (p 0.912) → +0.33 (p 0.383)receipt 5839
Swarm cases
receipt 5839: TMPRSS11D in dopamine neurons, braak
- power
- full sample +0.14 (p 0.591, n 18), 95% CI -0.35 to +0.57. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.14 (p 0.573, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.14 (p 0.573, n 18). could be the mix.
- skeptic
- leave-one-out range +0.04 to +0.28, sign flips 0; without severely affected donors +0.14 (p 0.591, n 18). fragile.
- cell type
- strongest in oligodendrocytes: +0.78 (p 1.3e-4, n 18) vs +0.14 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TMPRSS11D in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up TMPRSS11D · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.05 p 0.859 (needs p < 3.4e-4)
Receipts
loading the receipts