parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.02 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in ependymal cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 8081

TMEM47 in dopamine neurons, braak+0.42 (p 0.255) → -0.05 (p 0.891)receipt 8089
TMEM47 in astrocytes, braak-0.26 (p 0.498) → +0.15 (p 0.701)receipt 8088

receipt 8089: TMEM47 in dopamine neurons, braak

power: full sample +0.20 (p 0.429, n 18), 95% CI -0.30 to +0.61. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.37 (p 0.135, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.40 (p 0.097, n 18). could be the mix.
skeptic: leave-one-out range +0.11 to +0.33, sign flips 0; without severely affected donors +0.20 (p 0.429, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TMEM47 in dopamine neurons.

case closed: nothing better to follow up.

receipt 8088: TMEM47 in astrocytes, braak

power: full sample +0.04 (p 0.861, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.04 (p 0.881, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.10 (p 0.683, n 18). could be the mix.
skeptic: leave-one-out range -0.07 to +0.17, sign flips 3; without severely affected donors +0.04 (p 0.861, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TMEM47 in astrocytes.

case closed: nothing better to follow up.

loading the receipts