Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.10 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including microglia; strongest in lymphatic endothelial cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 2772
Sealed predictions
- TMEM255B in dopamine neurons, braak-0.39 (p 0.296) → -0.22 (p 0.567)receipt 2780
- TMEM255B in microglia, braak-0.36 (p 0.336) → +0.53 (p 0.146)receipt 2779
Swarm cases
receipt 2780: TMEM255B in dopamine neurons, braak
- power
- full sample -0.27 (p 0.285, n 18), 95% CI -0.65 to +0.23. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.30 (p 0.225, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.30 (p 0.221, n 18). could be the mix.
- skeptic
- leave-one-out range -0.40 to -0.17, sign flips 0; without severely affected donors -0.27 (p 0.285, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TMEM255B in dopamine neurons.
case closed: nothing better to follow up.
receipt 2779: TMEM255B in microglia, braak
- power
- full sample -0.02 (p 0.928, n 18), 95% CI -0.48 to +0.45. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.08 (p 0.767, n 18). does not hold up.
- composition
- microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.03 (p 0.901, n 18). could be the mix.
- skeptic
- leave-one-out range -0.14 to +0.11, sign flips 7; without severely affected donors -0.02 (p 0.928, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TMEM255B in microglia.
case closed: nothing better to follow up.
Receipts
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