Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in oligodendrocyte progenitor cells (48 nCPM) | 1.00 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 11060
Sealed predictions
- TMEM255A in dopamine neurons, braak-0.20 (p 0.602) → +0.26 (p 0.493)receipt 11069
- TMEM255A in oligodendrocytes, braak+0.82 (p 0.006) → -0.84 (p 0.005)receipt 11068
Swarm cases
receipt 11069: TMEM255A in dopamine neurons, braak
- power
- full sample +0.02 (p 0.949, n 18), 95% CI -0.45 to +0.48. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.14 (p 0.579, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.12 (p 0.627, n 18). could be the mix.
- skeptic
- leave-one-out range -0.14 to +0.14, sign flips 5; without severely affected donors +0.02 (p 0.949, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TMEM255A in dopamine neurons.
case closed: nothing better to follow up.
receipt 11068: TMEM255A in oligodendrocytes, braak
- power
- full sample -0.22 (p 0.389, n 18), 95% CI -0.62 to +0.28. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.23 (p 0.351, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.09 (p 0.735, n 18). could be the mix.
- skeptic
- leave-one-out range -0.33 to -0.10, sign flips 0; without severely affected donors -0.22 (p 0.389, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TMEM255A in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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