Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.23 (overall 0.15) | 0.23 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in cone photoreceptor cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 10 | 0.85 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 2201
Sealed predictions
- TMEM229B in oligodendrocytes, braak+0.07 (p 0.859) → -0.39 (p 0.297)receipt 2209
- TMEM229B in dopamine neurons, braak+0.16 (p 0.685) → -0.43 (p 0.247)receipt 2210
Swarm cases
receipt 2210: TMEM229B in dopamine neurons, braak
- power
- full sample -0.22 (p 0.379, n 18), 95% CI -0.62 to +0.27. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.23 (p 0.355, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.44 (p 0.070, n 18). could be the mix.
- skeptic
- leave-one-out range -0.34 to -0.11, sign flips 0; without severely affected donors -0.22 (p 0.379, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TMEM229B in dopamine neurons.
case closed: nothing better to follow up.
receipt 2209: TMEM229B in oligodendrocytes, braak
- power
- full sample -0.20 (p 0.418, n 18), 95% CI -0.61 to +0.29. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.29 (p 0.243, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.46 (p 0.055, n 18). could be the mix.
- skeptic
- leave-one-out range -0.32 to -0.10, sign flips 0; without severely affected donors -0.20 (p 0.418, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TMEM229B in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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