parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.02 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in neutrophils	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	11 Parkinson's papers of 2,170	0.67
pathways Reactome	8 pathways; mostly immune signalling	0.90

No case: the score is under the bar. Receipt 7224

receipt 7233: TLR1 in dopamine neurons, braak

power: full sample -0.09 (p 0.709, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.09 (p 0.709, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.01 (p 0.962, n 18). could be the mix.
skeptic: leave-one-out range -0.22 to +0.02, sign flips 1; without severely affected donors -0.09 (p 0.709, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TLR1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 7232: TLR1 in microglia, braak

power: full sample +0.02 (p 0.949, n 18), 95% CI -0.45 to +0.48. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.17 (p 0.504, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.19 (p 0.439, n 18). could be the mix.
skeptic: leave-one-out range -0.12 to +0.17, sign flips 5; without severely affected donors +0.02 (p 0.949, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TLR1 in microglia.

case closed: nothing better to follow up.

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