Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.05 (overall 0.03) | 0.05 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 75 | 0.91 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 6644
Sealed predictions
- TLK2 in dopamine neurons, braak+0.11 (p 0.787) → +0.48 (p 0.186)receipt 6653
Swarm cases
receipt 6653: TLK2 in dopamine neurons, braak
- power
- full sample +0.22 (p 0.384, n 18), 95% CI -0.28 to +0.62. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.23 (p 0.369, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.28 (p 0.261, n 18). could be the mix.
- skeptic
- leave-one-out range +0.11 to +0.30, sign flips 0; without severely affected donors +0.22 (p 0.384, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TLK2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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