Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 140 | 0.91 |
| pathways Reactome | 14 pathways; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 5477
Sealed predictions
- TINF2 in dopamine neurons, braak+0.01 (p 0.982) → -0.31 (p 0.414)receipt 5485
Swarm cases
receipt 5485: TINF2 in dopamine neurons, braak
- power
- full sample -0.07 (p 0.774, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.07 (p 0.774, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.13 (p 0.615, n 18). could be the mix.
- skeptic
- leave-one-out range -0.17 to +0.06, sign flips 3; without severely affected donors -0.07 (p 0.774, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TINF2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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