Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.13 from other evidence | 0.00 |
| cell type Human Protein Atlas | enriched in the midbrain (417 nTPM), where the nigral dopamine neurons sit | 0.90 |
| chemistry Open Targets | compounds already reach it: metyrosine | 1.00 |
| trials ClinicalTrials.gov | 34 Parkinson's trials, 2 stopped | 0.95 |
| literature PubMed | 3,970 Parkinson's papers of 82,892: well-trodden | 0.00 |
| pathways Reactome | 1 pathway; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 2243
Sealed predictions
- TH in dopamine neurons, braak-0.21 (p 0.586) → -0.68 (p 0.045)receipt 2252
In the sealed studies
Swarm cases
receipt 2252: TH in dopamine neurons, braak
- power
- full sample -0.45 (p 0.062, n 18), 95% CI -0.76 to +0.02. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.43 (p 0.075, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.45 (p 0.062, n 18). could be the mix.
- skeptic
- leave-one-out range -0.56 to -0.37, sign flips 0; without severely affected donors -0.45 (p 0.062, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TH in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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