Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.24 (overall 0.15) | 0.24 |
| cell type Human Protein Atlas | cell type enriched outside the brain (tuft cells) | 0.10 |
| chemistry Open Targets | hard to drug | 0.40 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 5 Parkinson's papers of 43 | 0.76 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 2176
Sealed predictions
- TGM6 in dopamine neurons, braak-0.05 (p 0.893) → -0.34 (p 0.367)receipt 2182
Swarm cases
receipt 2182: TGM6 in dopamine neurons, braak
- power
- full sample -0.22 (p 0.389, n 18), 95% CI -0.62 to +0.28. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.37 (p 0.135, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.40 (p 0.097, n 18). could be the mix.
- skeptic
- leave-one-out range -0.35 to -0.12, sign flips 0; without severely affected donors -0.22 (p 0.389, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TGM6 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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