Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 8 Parkinson's papers of 1,832 | 0.71 |
| pathways Reactome | 12 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 7730
Sealed predictions
- TCF7L2 in dopamine neurons, braak+0.48 (p 0.190) → -0.29 (p 0.443)receipt 7737
Swarm cases
receipt 7737: TCF7L2 in dopamine neurons, braak
- power
- full sample -0.06 (p 0.827, n 18), 95% CI -0.51 to +0.42. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.01 (p 0.962, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.16 (p 0.515, n 18). could be the mix.
- skeptic
- leave-one-out range -0.14 to +0.07, sign flips 4; without severely affected donors -0.06 (p 0.827, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TCF7L2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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